Tmub1 negatively regulates liver regeneration via inhibiting …
WEBHere, we show that in vivo transfection of Tmub1 overexpression vectors impaired mouse liver regeneration after partial hepatectomy (PHx). Loss- and gain-of-function analyses in human hepatocyte Lo2 cells indicated that Tmub1 inhibits the phosphorylation of STAT3 and the activation of STAT3 signaling.
Promoting anti-tumor immunity by targeting TMUB1 to modulate …
WEBNov 14, 2022 · A synthetic peptide engineered to compete with TMUB1 significantly promotes antitumor immunity and suppresses tumor growth in mice. These findings identify TMUB1 as a promising...
Tmub1 Suppresses Hepatocellular Carcinoma by Promoting the ...
WEBSep 9, 2020 · Transmembrane and ubiquitin-like domain-containing 1 (Tmub1) inhibits hepatocyte proliferation during liver regeneration, but its role in hepatocellular carcinoma (HCC) has yet to be revealed.
Transmembrane and Ubiquitin-Like Domain Containing 1 (Tmub1) …
WEBJun 22, 2010 · Tmub1 (C7orf21/HOPS) encodes a protein containing a ubiquitin-like domain. Tmub1 is highly expressed in the nervous system. To study its physiological function, we generated mice with Tmub1 deleted by homologous recombination. The knockout mice were grossly normal and viable.
The Ins and Outs of HOPS/TMUB1 in biology and pathology
WEBAug 29, 2020 · Mice treated with cAMP or EGF show a rapid shuttling of HOPS to cytoplasm, followed by HOPS return into the nucleus, supporting the hypothesis that its exit mediates cell proliferation. In vitro experiments in hepatoma cell lines demonstrated a role for HOPS in cell proliferation.
Microarray analysis reveals Tmub1 as a cell cycle-associated …
WEBJan 17, 2018 · Transmembrane and ubiquitin-like domain containing protein 1 (Tmub1), also named hepatocyte odd protein shuttling (HOPS)/DULP, is a key factor regulating liver-specific biological events, such as protein synthesis during liver regeneration, by binding to elongation factor eEF-1A .
Tmub1 negatively regulates liver regeneration via inhibiting …
WEBMar 1, 2019 · Tmub1 (transmembrane and ubiquitin-like domain-containing 1) plays negative roles in rat hepatocyte proliferation, but its underlying molecular mechanisms in liver regeneration regulation have yet to be revealed. Here, we show that in vivo transfection of Tmub1 overexpression vectors impaired mouse liver regeneration after partial hepatectomy ...
TMUB1 Correlated with Immune Infiltration Is a Prognostic …
WEBTransmembrane and ubiquitin-like domain-containing protein 1 (TMUB1), first reported in 2005, is significantly increased during liver regeneration . TMUB1 is overexpressed in a high number of human tumors. The overexpression of TMUB1 in tumor cell lines was shown to strongly reduce proliferation by arresting the cell cycle in G0/G1 . TMUB1 is a ...
WEBHOPS/Tmub1 is a ubiquitously expressed transmembrane ubiquitin-like protein that shuttles between nucleus and cytoplasm during cell cycle progression. HOPS causes cell cycle arrest in G0/G1...
WEBTmub1 (C7orf21/HOPS) encodes a protein containing a ubiquitin-like domain. Tmub1 is highly expressed in the nervous system. To study its physiological function, we generated mice with Tmub1 deleted by homologous recombination. The knockout mice were grossly normal and viable.
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