Macon is a city in and the county seat of Macon County, Missouri, United States. The population was 5,457 at the 2020 census. Macon was pl…Macon is a city in and the county seat of Macon County, Missouri, United States. The population was 5,457 at the 2020 census. Macon was platted in 1856. Like the county, Macon was named for Nathaniel Macon. A post office called "Macon City" was established in 1856, and the name was changed to Macon in 1892.
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